Looks like a growth on blackberry vine

Hillsborough, NC(Zone 7b)

I took these pictures at a client's house. Frankly, I'm going to pull out these plants no matter what, because they're in a flower bed and working around them is painful (scratches, they have killer thorns.) However, I'd like to know if I need to treat the area for anything, since I've never seen growths like these on blackberry before. These pics are of one of about ten that I ran across, all roughly the same size. My hand is in the first pic for size perspective. Is this caused by insects, fungus...? Something in the soil, maybe?

Thumbnail by SummerStorm93 Thumbnail by SummerStorm93

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