advise for long distance drive with cats

columbia, TN(Zone 7a)

We will be driving from NY to TN at the end of the month and have 5 cats and a dog. Planning on spending one night in a pet friendly hotel. Have one catt that is an outdoor cat and doesn't get along with the others, anotherr one that will only let me pet her when I am on the toilet(don't know how I am going to get her in a carrrier) is there anything I can give them to help them relax and enjoy the trip I would prefer something natural. Thanks.

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